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身体形状表型,TYG轨迹和消化系统癌症的风险
Zixiang Kai1,2,3, Chenan Liu4, Qingsong Zhang5
1School of Forensic Medicine, Shanxi Medical University, Jinzhong, China.
甘油三糖 (TyG) 指数轨迹,而不是单个测量,更好地预测消化系统癌症风险. 保持高的TyG指数与不健康的身体形状和癌症风险增加有关,特别是结肠直肠和胃癌.
科学领域:
- 代谢健康和慢性疾病流行病学
- 胰岛素抵抗生物标志物 胰岛素抵抗生物标志物
- 消化系统瘤学 消化系统瘤学
背景情况:
- 甘油三糖 (TyG) 指数和身体形状是胰岛素抵抗的指标,与慢性疾病有关.
- TyG指数变化与消化道癌症风险之间的纵向关系尚不清楚.
研究的目的:
- 为了研究甘油-葡萄糖 (TyG) 指数的纵向模式.
- 评估TyG指数轨迹与发展消化系统癌症的风险之间的关联.
- 探索TyG指数轨迹与癌症风险中的身体形状表型之间的相互作用.
主要方法:
- 利用隐性混合模型在一个大前景队列中识别不同的TyG指数轨迹 (Kailuan研究).
- 采用主要成分分析来表征身体形状表型.
- 应用考克斯回归模型来分析已识别的TyG指数轨迹与消化系统癌症发病率之间的关系.
主要成果:
- 在53,350名参与者中确定了五种不同的TyG指数轨迹和四种身体类型表型.
- 与单个测量相比,TyG指数轨迹显示了消化癌风险的优异预测价值.
- 较高的TyG指数轨迹 (中等高稳定,高稳定,高增长) 与较低稳定的轨迹相比,与增加的消化道癌症风险 (HRs 1.42-2.48) 有显著的关联.
- 观察到结直肠和胃癌风险的一致趋势.
结论:
- 纵向TyG指数轨迹在预测消化系统癌症风险方面比单个测量更有效.
- 持续高的TyG指数轨迹与不利的身体形状和消化系统癌症的风险增加相关,特别是结肠直肠和胃类型的癌症.
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