关于乌斯特基努马布和瑞桑基努马布对克罗恩氏病的有效性的现实数据
Ryo Morikawa1, Toshimitsu Fujii1, Akiko Tamura1
1Department of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Inflammatory intestinal diseases
|October 9, 2025
概括
瑞桑基祖马布 (RZB) 在克罗恩氏病 (CD) 治疗中显示出比乌斯特基努马布 (UST) 更高的短期疗效. 这两种疗法在现实研究中都显示出可接受的安全性.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 克罗恩氏病 (CD) 是一种慢性炎症性肠病.
- 乌斯特基努马布 (UST) 和瑞桑基努马布 (RZB) 是用于CD的生物疗法.
- 在CD中对UST和RZB的真实世界比较疗效数据有限.
研究的目的:
- 在克罗恩氏病 (CD) 患者中比较乌斯特基努马布 (UST) 和瑞桑基祖马布 (RZB) 的实际疗效和安全性.
主要方法:
- 从2017年5月到2024年3月接受UST或RZB治疗的CD患者的回顾性分析.
- 在第8周和第28周使用哈维-布拉德肖指数 (HBI ≤4) 评估的临床缓解.
- 包括111名UST患者和29名RZB患者.
主要成果:
- 在第8周 (82.8% vs. 62.2%) 和第28周 (79.3% vs. 56.8%),瑞桑基祖马布 (RZB) 的临床缓解率高于乌斯特基努马布 (UST).
- 这些疗效差异在整体队列和患有活跃疾病或先前暴露于抗TNFα的患者的子组中是显著的.
- 不良事件很少发生,其中有一次是RZB住院治疗,一次是UST停止治疗.
结论:
- 与克罗恩病的乌斯特基努马布 (UST) 相比,瑞桑基祖马布 (RZB) 似乎在短期内具有更高的疗效.
- 这两种生物在现实临床实践中都表现出可接受的安全性.
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