梅萨拉药丸负担对炎症性肠病患者合规性的影响
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Julien Kirchgesner1, Helen Thorne2, Ekaterina Safroneeva2,3
1Department of Gastroenterology, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Hôpital Saint-Antoine, Sorbonne Université, Paris, France.
强度更高的梅萨拉片改善了炎症性肠病 (IBD) 患者的药物坚持和持续性. 每天减少药片数量显著提高了患者对口服梅萨拉治疗的坚持.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 现实世界的证据研究研究.
背景情况:
- 有限的研究使用现实世界药房索赔数据探索梅萨拉的持久性和坚持性.
- 了解坚持对于有效的炎症性肠病 (IBD) 管理至关重要.
研究的目的:
- 根据分发的片剂强度,根据IBD患者的口服梅萨拉粘附度进行比较.
- 为了评估药丸负担对美萨拉持续性和坚持性的影响,在现实环境中.
主要方法:
- 使用法国零售药店索赔数据 (IQVIA纵向处方数据) 的回顾性队列研究.
- 包括12122名IBD治疗先前的患者开始服用口服梅萨拉.
- 在高强度 (HS),中强度 (MS) 和低强度 (LS) 的梅萨拉片组中比较坚持和持久性.
主要成果:
- 与MS (35.5%,35.4%) 和LS (28.0%,25.3%) 组相比,高强度 (1600毫克) 梅萨拉片的坚持 (41.3%) 和持续6个月 (44.6%) 显着更高.
- 在1年后的持久性也是HS片 (22.0%) 与MS (17.1%) 和LS (11.5%) 相比更高.
- 观察到一贯的趋势是较高的坚持,降低了药片负担.
结论:
- 高强度梅萨拉片与IBD患者的药物持续性和药物坚持性显著改善有关.
- 通过更强度的配方来减少每日药片负担,可以提高患者对口服梅萨拉治疗的遵从性.
- 研究结果支持使用更强度的梅萨拉片来优化IBD治疗结果.
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