基于舌头特征的模型用于评估类风湿性关节炎患者的疾病活性
Yuxin Han1, Zihan Wang2, Meiqi Lan1
1Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in pharmacology
|October 9, 2025
概括
这项研究引入了一种新型模型,通过将舌头特征与实验室标记器相结合来评估类风湿性关节炎 (RA) 活动. 这种新模型在预测RA疾病活动方面表现出高准确性和临床实用性.
科学领域:
- 类风湿病学 类风湿病学
- 医疗成像医学成像
- 生物标志物 生物标志物
背景情况:
- 舌头的特征是新兴的成像生物标志物,在疾病预测中具有潜在的应用.
- 它们在评估类风湿性关节炎 (RA) 活动中的实用性以前没有被探索.
- 这项研究研究了舌头特征在RA活动评估模型中的整合.
研究的目的:
- 开发一种临床上适用的模型来评估RA活性.
- 分析特定的舌头特征和RA的实验室指标之间的关系.
- 为了比较一个包含舌头特征的模型与仅使用实验室参数的模型的预测性能.
主要方法:
- 227名RA患者被招募并分为缓解/低活性和中度/高活性组.
- 使用多变量逻辑回归开发了两个预测模型:模型1 (实验室参数) 和模型2 (实验室参数加舌头特征).
- 用ROC曲线,校准图和决策曲线分析来评估模型性能.
主要成果:
- 模型1包括白细胞 (WBC),血红蛋白 (HGB),血小板 (PLT) 和IgA.
- 模型2采用了WBC,HGB,油性涂层和下舌,表现优于模型1.
- 模型2实现了曲线下的面积为0.846,灵敏度为0.63和特异性为0.826.
结论:
- 开发了一种初步的RA疾病活动评估模型,整合了舌头特征和实验室参数.
- 这种新型模型显示出高精度和临床实用性的巨大潜力.
- 这些发现表明,舌头特征可以在RA评估中作为有价值的生物标志物.
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