在状细胞贫血和血症中对鼻腔的放射性评估:病例对照研究
Maha A Alharbi1, Ayat AlDarwish2, Reem M Alamier2
1Department of Otolaryngology-Head and Neck Surgery Dammam Medical Complex, Eastern Health Cluster Dammam Saudi Arabia.
Laryngoscope investigative otolaryngology
|October 9, 2025
概括
状细胞病和血病导致上鼻壁加厚. 这些变化可以模仿其他疾病,给医生带来诊断挑战.
科学领域:
- 血液学 血液学 血液学
- 放射学 放射学是一门学科.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 状细胞病 (SCD) 和血病是遗传性血液疾病,导致慢性血液溶解性贫血.
- 这些情况可能导致骨髓功能障碍和外骨髓造血.
- 病理生理学变化可能导致鼻并发症或在成像上误诊.
研究的目的:
- 在患有状细胞贫血 (SCA),β-thalassemia (β-thalassemia) 和状细胞β-thalassemia (SCAβ-thalassemia) 的患者中评估上鼻异常.
主要方法:
- 一个多中心的病例控制研究包括212名参与者 (100个对照组,51个SCA,15个β-血症,46个SCAβ-血症).
- 收集的数据包括人口统计,血红蛋白水平,电泳,酸使用,以及输血史.
- 计算机断层扫描 (CT) 评估了鼻壁厚度,外骨膜造血和鼻异常.
主要成果:
- 在所有疾病群体中都观察到显著的上鼻壁加厚,在β-thalassemia中最明显 (p < 0.001).
- 在SCA中,血红蛋白水平和鼻壁厚度之间存在负相关性.
- 在五名β-thalassemia患者中发生了罕见的外骨髓性血液形成;骨髓死复合物阻塞因组而异.
结论:
- 显著的上鼻腔壁加厚是SCA,β-thalassemia和SCAβ-thalassemia的常见发现.
- 放射科医生和耳鼻喉科医生必须识别这些结构变化,以避免误诊.
- 了解这些异常对于准确解释这些患者群体中鼻腔成像至关重要.
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