免疫检查点抑制剂 - 关联管化和原性糖尿病无味症:一个病例报告
Ido Cohen1,2, Loaa Qormata2,3, Orit Erman2,4
1Department of Medicine E, Sheba Medical Center Tel-Hashomer, Ramat Gan, Israel.
Case reports in nephrology and dialysis
|October 9, 2025
概括
布罗利祖马布是一种免疫疗法药物,可以引起脏问题,如急性脏损伤,管性酸性,原性无味糖尿病. 及时识别和用皮质类固醇治疗可以逆转这些与免疫相关的不良事件.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫疗法,特别是免疫检查点抑制剂,如 pembrolizumab,已经彻底改变了癌症治疗.
- 然而,这些疗法可以诱导与免疫相关的不良事件 (irAEs),包括严重的并发症.
- 脏irAEs可以以各种形式表现,影响管状和状细胞功能.
研究的目的:
- 在患有恶性黑色素瘤的患者中报告一次性急性损伤的病例,该病例是 pembrolizumab 治疗的次要病例.
- 突出罕见的并发症的临床表现和管理,特别是管酸性和原性无味糖尿病.
主要方法:
- 一个42岁的患有恶性黑色素瘤的女性患者接受辅助 pembrolizumab 的病例介绍.
- 临床表现的详细描述,包括急性损伤,蛋白尿,RTA和NDI在内的实验室发现.
- 管理策略的概述,包括药物停用,皮质类固醇治疗和电解质校正.
主要成果:
- 患者出现了严重虚弱,肌痛,腹痛,多尿和口渴的症状.
- 实验室调查证实了急性损伤,蛋白尿,带电解质干扰的RTA和NDI.
- 用普得尼松治疗和支持性护理导致了快速的临床改善和功能正常化.
结论:
- 这一案例强调了对与免疫检查点抑制剂相关的脏并发症保持警的必要性.
- 早期识别和及时管理irAEs如RTA和NDI对于预防不可逆转的损伤至关重要.
- 临床医生的意识是优化免疫治疗期间患者结果的关键.
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