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Updated: Jan 15, 2026

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对TGFβ1-诱导的活性蛋白A基因表达在脏中细胞中的分析

Asfia Soomro1, Ifeanyi Kennedy Nmecha1, Jackie Trink1

  • 1Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Canada.

Frontiers in molecular biosciences
|October 9, 2025
PubMed
概括

转化生长因子β1 (TGFβ1) 调高活性蛋白A,这是纤维化的一个关键驱动因素. 这项研究确定了Stat5和FoxP1作为激素A生产的关键调节者,为纤维化提供了潜在的治疗点.

关键词:
在TGFβ1中.活性蛋白 A 是一种活性蛋白.脏纤维化 脏纤维化活动促进者活动的推动者.监管要素 监管元素 监管元素

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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