喘息吸烟者与非吸烟者的支气管扩展前和后螺旋测量:基于医院的横截面研究
Yassine Wael Mohamed Elshammaa1, Dana Mhd Nabil Bendakji2, Sherif Elseedy3
1Faculty of Medicine, Alexandria University, Alexandria, EGY.
Cureus
|October 9, 2025
概括
烟草吸烟显著损害肺功能,比非吸烟者显示较低的螺旋计结果. 支气管扩展剂在两组患者中都改善了肺功能,但吸烟者改善程度较低,这凸显了早期查的必要性.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 吸烟是导致肺功能下降和慢性呼吸道疾病的主要危险因素.
- 通过螺旋计提前检测肺部变化对于及时干预和预防长期并发症至关重要.
研究的目的:
- 为了比较吸烟者和非吸烟者之间的螺旋计参数.
- 评估支气管扩展剂给药对两组患者肺功能的影响.
主要方法:
- 一项涉及60名参与者的横截面研究 (30名吸烟者,30名非吸烟者).
- 在支气管扩展剂服用之前和之后进行了螺旋计.
- 测量的主要参数包括生命能力 (VC%),强迫生命能力 (FVC%),1秒内强迫呼吸量 (FEV1%),FEV1/FVC比率,FEF25-75%,MVP%和呼吸时间.
主要成果:
- 与非吸烟者相比,吸烟者在所有测量参数中表现出明显较低的基线螺旋计值 (p < 0.001).
- 两组人都表现出支气管扩张后肺功能显著改善 (p < 0.001),而吸烟者表现出较小程度的改善.
- 在吸烟者中,1秒内强迫呼气量 (FEV1%) 从47.2%增加到60.3%,在非吸烟者中从56.3%增加到73.3%.
结论:
- 吸烟与肺功能大幅降低和支气管扩展剂反应减弱有关.
- 吸烟者的早期螺旋计查对于识别功能衰退至关重要.
- 这些发现支持戒烟和有针对性的治疗策略的必要性,以防止肺部疾病的进展.
相关概念视频
COPD: Management Using Bronchodilators and Corticosteroids
726
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
726
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
Asthma-IV: Diagnostic and Management
3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Pulmonary Function Tests
733
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
733
Antiasthma Drugs: β2-Adrenoceptor Agonists
1.6K
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
1.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K


