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心理社会压力与心肌组织特征之间的关系中的性别差异:一项CMR成像研究
Mayssa Moukarzel1,2, Kian Soroush1, Yixing Zhang3
1Department of Medicine and Health Sciences (M.M., K.S., M.G.F., J.M.L.), McGill University, Montreal, QC, Canada.
Circulation. Cardiovascular imaging
|October 9, 2025
概括
心理社会压力会影响女性的心脏健康,导致心肌早期变化. 在男性中没有观察到这些变化,这突出了性别特异性的应激反应和在女性心血管风险评估中需要考虑心理社会因素的必要性.
科学领域:
- 心脏病学 心脏病学
- 精神病体医学是一种精神病体医学.
- 医疗成像医学成像
背景情况:
- 心理社会压力是心血管疾病 (CVD) 的已知危险因素.
- 与男性相比,女性对心血管疾病发展的压力影响更为明显.
- 早期发现亚临床心肌变化对于预防心血管疾病至关重要.
研究的目的:
- 调查性别差异在感知压力和心肌组织特征之间的关联.
- 评估心理社会负担对这些协会的贡献,包括照顾和社会地位.
- 用心血管磁共振成像 (CMR) 与本地T1和T2映射来评估心肌组织特征.
主要方法:
- 招募了219名没有明显心血管疾病的参与者 (53.9%为女性,平均年龄为54.4岁).
- 评估了感知到的压力,家庭照顾和感知到的情感支持.
- 用本地T1和T2映射进行CMR测试,以评估心肌组织.
主要成果:
- 高压力女性的T1时间 (心肌组织变化) 比低压力女性要长得多.
- 风险组中高压力女性的T2时间也更长.
- 感知到的压力预测了女性的T1值,但不是男性. 护理负担和情感支持是女性T1的独立预测因素.
结论:
- 心理社会压力与女性早期的亚临床心肌变化有关,但与男性无关.
- 性别特定的途径可能解释了压力如何影响心肌重塑.
- 心理社会因素应纳入妇女心血管风险评估.
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