相关实验视频

Updated: Jan 15, 2026

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

与年龄相关的炎症单细胞在绝经女性中增加,并通过激素替代疗法逆转

R P H De Maeyer¹, J Sikora², O V Bracken³

¹The Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK.

|October 9, 2025

概括

老龄化的雌性表现出炎症单细胞的增加,与减少的细胞化有关. 在绝经前/更年期妇女中,激素替代疗法 (HRT) 逆转了这些变化,改善了单细胞功能,并可能增强免疫力.

科学领域:

免疫学免疫学免疫学
老年学是指老年学的学科.
内分泌学在内分泌学.

背景情况:

生物性别和衰老显著影响感染易感性,但它们对人类单细胞表型和功能的影响仍未得到充分研究.
单细胞是关键的免疫细胞,参与炎症反应;它们的种群变化与感染风险增加有关.

研究的目的:

研究衰老和生物性别对人类单细胞表型和功能的影响.
确定单细胞子集中的与年龄和性别相关的变化及其功能影响.

主要方法:

对年轻女性和年长女性单细胞群 (中等和非经典) 的比较分析.
对排序单细胞子集的蛋白质组学分析,以确定不同的表型和与年龄相关的蛋白质通路.
评估补充剂 (C3) 度和单细胞细胞能力.
评估激素替代疗法 (HRT) 对单细胞表型,CRP水平,C3度和临/更年期女性的细胞化的影响.

主要成果:

年长的女性表现出炎症中间和非经典单细胞的扩张,与炎症标志物相关联.
蛋白质组分析揭示了单细胞子集中不同的表型,补充级联和细胞形成途径的年龄相关变化.
在女性 (而不是男性) 中,循环C3水平随着年龄的增长而下降,导致单细胞细胞减少.
在近期/更年期的女性中,HRT逆转了中间单细胞扩张,降低了CRP,增加了C3血清度,并显著改善了单细胞化.

结论:

更年期对女性老龄化过程中的单细胞表型和功能产生重大影响.
HRT显示出恢复与年龄相关的单细胞功能下降和改善女性抗病原体免疫力的潜力.
了解性别和年龄特定的免疫变化对于开发针对性干预措施来对抗与年龄相关的感染至关重要.

更多相关视频

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

相关概念视频

Menopause

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Hormonal Regulation of the Menstrual Cycle

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...

Inflammation

Inflammation

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...