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在西班牙裔社区健康研究/拉丁裔研究中的肠道微生物组和认知功能
Natalia Palacios1,2,3, Scott Gordon1, Tao Wang4
1Department of Public Health, University of Massachusetts Lowell, Lowell, MA, USA.
Journal of Alzheimer's disease : JAD
|October 9, 2025
概括
这项研究探讨了肠道微生物群.
科学领域:
- 微生物组研究 微生物组研究
- 神经科学是一个神经科学.
- 西班牙裔/拉丁裔健康
背景情况:
- 在拉丁裔人群中,关于肠道微生物组在阿尔茨海默病和相关痴呆症 (AD/ADRD) 中的作用的研究有限.
- 了解这些联系对于认知衰退中的健康差异至关重要.
研究的目的:
- 研究大批西班牙裔/拉丁裔群体的肠道微生物组成和认知功能之间的关联.
- 确定特定的微生物种群和与认知表现相关的功能途径.
主要方法:
- 分析了来自西班牙裔社区健康研究/拉丁裔研究 (HCHS/SOL) 的2471名参与者的便元基因组数据.
- 统计分析 (PERMANOVA,MaAsLin2) 用于确定微生物特征与全球认知功能之间的关联.
- 研究了特定的微生物物种和基因和基因组的京都百科全书 (KEGG) 途径.
主要成果:
- 一些细菌物种,包括Eubacterium siraeum,Eubacterium eligens和Clostridium phocaeense,与更好的认知功能有关.
- 特定的KEGG通路,特别是Ornithine,Serine生物合成和尿素循环,与较差的认知功能有关.
结论:
- 这项研究揭示了肠道微生物组与大量西班牙裔/拉丁裔群体的认知功能之间的重要关联.
- 已识别的微生物种群和代谢途径为未来对多种人群中ADRD预防和治疗的研究提供了潜在的目标.
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