身体活动,肠道微生物群,以及基于社区的队列研究中的失脂症风险
Wuqi Wang1, Shaoxian Liang1, Hongjuan Cao2
1Department of Nutrition, Center for Big Data and Population Health of IHM, School of Public Health Anhui Medical University Hefei China.
Journal of the American Heart Association
|October 9, 2025
概括
中度至强度的体力活动 (MVPA) 可以降低与久坐行为相关的失脂症风险. MVPA还影响肠道微生物群,这表明它在预防失脂症方面发挥着作用.
科学领域:
- 心血管健康 心血管健康
- 微生物组研究 微生物组研究
- 公共卫生 公共卫生
背景情况:
- 久坐不动行为,体力活动和脂质失调之间的关系尚未完全理解.
- 适度至剧烈的体力活动 (MVPA) 对肠道微生物群组成的影响及其与失脂症的联系需要进一步研究.
研究的目的:
- 检查MVPA和久坐时间对中国成年人失脂症风险的综合影响.
- 为了研究MVPA与肠道微生物群在一年内发生的变化之间的关联.
主要方法:
- 一项针对2942名中国成年人的前性研究,通过自我报告评估身体活动,并通过详细的PA日记和便样本的16SrRNA测序对子队 (n=754) 进行了评估.
- 对失脂症发病率,体力活动水平以及肠道微生物多样性 (α和β多样性) 和组成的纵向分析.
主要成果:
- 长时间的久坐运动显著增加了脂质不良症的风险 (HR 1.63).
- 较高的MVPA水平,特别是在"短高"静止/MVPA组中,与"长低"组相比,与降低的失脂症风险有关.
- MVPA调节了肠道微生物的α和β多样性,像Eggerthella和Desulfovibrio这样的特定属与MVPA和久坐时间相关,而Desulfovibrio与脂质不良症相反相关.
结论:
- MVPA可以减轻久坐不动行为对失脂症风险的不良影响.
- 通过MVPA调节肠道微生物群表明潜在的微生物群介导的途径,用于预防失脂症.
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