重新评估脂肪和头癌之间的联系:孟德尔的随机化研究
Fernanda Morales Berstein1,2, Jasmine Khouja1,2, Mark Gormley1,2,3
1MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
eLife
|October 9, 2025
概括
这项研究发现,当考虑到吸烟时,较高的体重指数 (BMI) 不会增加头癌 (HNC) 的风险. 像BMI,腰比和腰围这样的肥胖度量不是HNC的主要风险因素.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 肥胖与增加头癌 (HNC) 风险有关.
- 之前关于吸烟者的体重指数 (BMI) 和HNC风险的研究被混了.
- 门德尔随机化 (MR) 研究无法完全排除脂肪和HNC之间的因果关系.
研究的目的:
- 调查脂肪和头癌 (HNC) 风险之间的因果关系.
- 利用最大的可用的全基因组关联研究 (GWAS) 数据用于HNC,包括子站点信息.
- 澄清脂肪在HNC发育中的作用,考虑潜在的混因素.
主要方法:
- 采用两个样本的孟德尔随机化 (MR) 框架.
- 评估了BMI,腰比 (WHR) 和腰围对HNC风险的基因预测影响.
- 利用逆方差加权 (IVW) MR和多变量MR (MVMR) 来考虑吸烟行为.
主要成果:
- 较高的基因预测BMI显示,在不变MR中,整体HNC的风险增加.
- 当吸烟被纳入多变量MR模型时,这种关联减弱并不再显著.
- 在基因预测的WHR或腰围和HNC风险之间没有发现显著的联系.
结论:
- 肥胖,包括BMI,WHR和腰围,似乎不是头癌 (HNC) 的主要因果风险因素.
- 在以前的研究中观察到的脂肪和HNC风险之间的关联可能会被吸烟等因素所混.
- 进一步的研究应集中在其他已确定的HNC风险因素上.
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