艾滋病毒感染者中精神分裂症谱系障碍的风险:全国范围的,基于人口的,匹配的队列研究
Cecilie V Vollmond1, Malte M Tetens1, Jan Gerstoft1
1Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
AIDS (London, England)
|October 9, 2025
概括
艾滋病毒感染者 (PWH) 患精神分裂症谱系障碍 (SSD) 的风险大大增加,特别是那些有注射药物使用 (IDU) 史的人. 家庭因素也可能在这种高风险中发挥作用.
科学领域:
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 心理健康是艾滋病毒感染者 (PWH) 越来越关注的问题.
- 精神分裂症谱系障碍 (SSD) 是一个重大的公共卫生挑战.
- 了解PWH中SSD的风险因素对于有针对性的干预至关重要.
研究的目的:
- 评估艾滋病毒感染者 (PWH) 中精神分裂谱系障碍 (SSD) 的风险.
- 通过检查兄弟队伍来调查家族因素对PWH中SSD风险的影响.
- 探索艾滋病毒传播途径如何影响SSD风险.
主要方法:
- 从1995年到2021年,丹麦进行了一项全国性的,基于人口的,匹配的队列研究.
- 数据包括艾滋病毒感染者 (PWH),匹配的比较队列和兄弟姐妹队列.
- 使用累积发病率函数和考克斯回归分析来估计风险和危险比率 (HR).
主要成果:
- 艾滋病毒感染者 (PWH) 的SSD风险显著增加 (累计发病率3.7%对1.0%;HR 4.6).
- 对于注射药物使用 (IDU) 作为艾滋病毒传播途径的PWH,风险特别高 (HR 11.3).
- 患有IDU的PWH兄弟姐妹也增加了SSD风险 (HR 2.9),这表明潜在的家族贡献.
结论:
- 精神分裂症谱系障碍 (SSD) 的风险在艾滋病毒感染者 (PWH) 中显著增加.
- 作为艾滋病毒传播途径的注射药物使用 (IDU) 与特别高的SSD风险有关.
- 家庭因素可能部分解释了在这个人群中观察到的SSD风险增加.
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