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优化基于结肠镜的结肠直肠癌查通过低障碍,低值预测

Thomas Heisser¹, Rafael Cardoso¹, Tobias Niedermaier¹

¹Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

International journal of cancer

|October 9, 2025

概括

与传统方法相比,使用敏感的便免疫化学测试 (FIT) 的创新"开门者"结肠镜查策略显著降低了结肠直肠癌 (CRC) 的发病率和死亡率. 较低的FIT门可以更好地预防CRC病例和死亡.

科学领域:

胃肠病学胃肠病学
预防医学预防医学
在瘤学瘤学.

背景情况:

传统的结直肠癌 (CRC) 查方法在准最有可能受益的个体方面存在局限性.
"开门者"概念建议使用敏感的便免疫化学测试 (FIT),具有较低的阳性值,以更好地选择结肠镜检查的个体.
优化这种方法可以提高CRC发病率和降低死亡率.

研究的目的:

探索"开门器"基于结肠镜查的最佳使用,以减少CRC发病率和死亡率.
用模拟来比较"开门者"查与传统的FIT和结肠镜查策略的有效性.

主要方法:

使用COSIMO模拟工具,这是一个验证的CRC查模型.
使用SENTiFIT-FOB Gold FIT在各种低血红蛋白切线点 (10,8,6,4和3μg/g便) 进行模拟的"门"查.
与传统查结肠镜检查和每两年一次的FIT进行"开门"查场景的比较结果.

主要成果:

6,4或3μg/g的切断值的开门查显著优于常规查结肠镜在减少CRC发病率方面 (10年内预防的病例增加了16%-72%).
所有的门方案都显著增加了预防CRC死亡的可能性,低切断值超过了传统结肠镜检查所达到的两倍.
与两年一次的FIT相比,开门查预防了7%-163%的CRC病例和12%-21%的CRC死亡,较低的切断值产生了更高的收益.

结论:

与传统查方法相比,基于"开门器"结肠镜的查在减少CRC发病率和死亡率方面表现出更高的有效性.
在"开门机"FIT中较低的血红蛋白检测值显著提高了查效率.
建议进行试点研究,以评估"开门者"查概念的现实可行性.

关键词:

结肠镜检查结肠镜检查结肠直肠癌是什么意思便免疫化学测试便免疫化学测试模拟建模的模型.查检查查检查查检查查检查

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