大奶粉是否在肠道适应中发挥作用? 一个系统的文献审查
Chiara Oreglio1, Sara Ugolini2, Antonino Morabito3
1School of Pediatric Surgery, University of Florence, Florence.
概括
在患有短肠综合征 (SBS) 的患者中,胆乳显示出耐受性. 然而,目前的研究缺乏足够的证据来证实其对肠道适应的益处,需要进一步调查.
科学领域:
- 新生儿营养新生儿营养
- 胃肠病学 胃肠病学
- 外科手术的结果
背景情况:
- 大奶粉富含生长因子和营养素,支持新生儿的适应.
- 它作为一种免疫保护剂的潜力得到了认可,特别是在早产婴儿身上.
- 短肠综合症 (SBS) 在肠道适应和营养吸收方面存在挑战.
研究的目的:
- 系统地审查现有的关于乳牛奶在增强SBS患者肠道适应作用的文献.
- 在动物模型和人类SBS病例中评估手术后大奶粉的疗效和安全性.
主要方法:
- 使用MEDLINE进行了系统的文献搜索.
- 纳入标准集中在英语语言的研究,涉及手术后给动物和患有SBS的人类施用乳房.
- 分析了十篇全文文章,包括动物模型,人类SBS患者和混合种群.
主要成果:
- 在动物或人体研究中,没有确定胆乳对肠道适应的明确益处.
- 结果受到试验稀缺,研究持续时间短,方法异质等因素的限制.
- 大奶粉在研究群体中表现出良好的耐受性.
结论:
- 目前的证据不足以支持常规使用胆乳来改善短肠综合征的肠道适应.
- 需要进一步进行精心设计的标准化研究,以确定在SBS管理中胆乳的潜在益处和最佳使用.
- 虽然可以容忍,但乳酪蛋白在SBS中的临床疗效仍未确定.
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