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Updated: Jan 15, 2026

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
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Published on: October 29, 2019

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全身麻醉和全身高度可调节雌性大鼠的腰椎内药物分发

Niklas Daniel Åke Persson1, Terhi J Lohela2, Jenni E Anttila3

  • 1Individualized Drug Therapy Research Program and Department of Pharmacology, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

Anesthesiology
|October 9, 2025
PubMed
概括

麻醉和高血压盐水 (HTS) 显著改变了脊髓药物在中枢神经系统 (CNS) 中的分布方式. 胺-德克斯梅德托米丁麻醉剂增强了脊柱药物输送,同时减少了大脑暴露,与异相反.

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