孕产妇甲状腺功能低下对早产和新生儿结果的影响:一项前性病例对照研究
Pratishtha Dubey1, Kanchan Singh2, Suman Singh1
1Department of Obstetrics and Gynaecology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Annals of African medicine
|October 9, 2025
概括
孕产妇甲状腺功能低下会增加早产和新生儿不良后果的风险,包括呼吸困扰综合征 (RDS). 孕妇早期发现和治疗甲状腺功能障碍对于改善婴儿健康至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿科学 新生儿科学
- 内分泌学 在内分泌学.
背景情况:
- 孕产妇的甲状腺功能低下与早产和潜在的新生儿并发症有关.
- 孕产妇甲状腺功能低下症对新生儿发病结果的具体影响,如呼吸应急综合征 (RDS) 和住院治疗,需要进一步阐明.
研究的目的:
- 为了检查母亲甲状腺功能低下症和早产之间的关联.
- 评估母亲甲状腺功能低下症对新生儿结果的影响,重点关注RDS和新生儿整体健康,以自发早产为例.
主要方法:
- 一项前性病例对照研究,涉及509名怀孕妇女,自发早产 (28-37周).
- 在69名甲状腺功能低下的母亲和431名甲状腺功能良好的对照人群中进行了比较.
- 通过TSH,T3,T4和抗TPO抗体评估母亲甲状腺功能;新生儿结局包括出生体重,妊娠年龄,RDS和带血TSH.
主要成果:
- 甲状腺功能下降的母亲经历了更高的早产发病率.
- 甲状腺功能低下母亲的新生儿,特别是患有亚临床甲状腺功能低下症的新生儿,出现RDS,新生儿重症监护室入院率增加,需要呼吸器支持.
- 在甲状腺功能低下的母亲的婴儿中观察到带血中TSH水平升高,与NICU停留时间较长和氧气需求增加相关.
结论:
- 孕产妇甲状腺功能低下症,包括亚临床形式,与早产和不良的新生儿结果有关.
- 在怀孕期间及时识别和管理母亲的甲状腺功能障碍可能会提高新生儿的健康,减少RDS发生率,并缩短NICU停留时间.
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