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Updated: Jan 15, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

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局部治疗克服了在不可切除的肝细胞癌中对目标免疫疗法组合的初级耐药性

Xiangqi Chen1,2, Mingjian Piao1, Zixiang Zhou2

  • 1State Key Laboratory of Complex Severe and Rare Diseases, Department of Liver Surgery, Peking Union Medical College Hospital, Beijing, China.

Cancer immunology, immunotherapy : CII
|October 9, 2025
PubMed
概括

在不可切除的肝细胞癌 (uHCC) 患者中,对免疫检查点抑制剂 (ICI) 的获得性耐药性 (AR) 在两年内发展,并且预后比原发性耐药性 (PR) 更好. 抗药后的治疗改善了两者的结果,特别是对AR.

关键词:
获得的电阻 获得的电阻肝细胞癌是肝细胞癌.免疫检查点抑制剂 免疫检查点抑制剂序列疗法是一种序列疗法.系统性疗法是一种全身疗法.

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