在社区居住的老年人中使用抗胆固醇药物的患病率和相关因素:系统性审查
Keren Pelen1,2, Willy-Brad Hagenimana1,2, Marie-Laure Baroud1,3
1Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Canada.
International journal of clinical pharmacy
|October 9, 2025
概括
抗胆固醇药物的使用在老年人中很常见,并且与性别,社会经济地位和并发症等健康因素有关. 干预措施应针对这些因素,以减少使用和潜在的危害.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 抗胆固醇药物经常被处方给老年人.
- 有证据表明,这些药物与老年人的身体和认知障碍有关.
- 尽管存在风险,但在社区居住的老年人群中,广泛使用仍然存在.
研究的目的:
- 系统地审查在社区居住的老年人中使用抗胆固醇药物的患病率.
- 为了确定与抗胆固醇药物使用相关的因素.
- 为了记录最常被处方的抗胆固醇药物类别.
主要方法:
- 在MEDLINE,Embase和CINAHL数据库中进行系统的文献搜索,截至2024年5月.
- 包括65岁以上社区成年人的研究,评估与抗胆固醇药物使用相关的因素.
- 利用AI进行查和Covidence进行全文审查,数据提取和质量评估 (纽卡斯尔-太华规模).
主要成果:
- 包括7项发表于2014-2021年期间的研究 (五项横截面研究,两项追溯研究).
- 较高的抗胆固醇负担与女性性别,较低的社会经济地位,并发症,脆弱性,多药性和医疗保健使用有关.
- 患病率差异很大 (6.2%至72.8%),抗抑郁药,抗胰岛素药和抗糖药是常见的类别.
结论:
- 确定了影响抗胆固醇药物的使用的关键社会经济和健康状况因素.
- 应针对这些因素进行干预,以减少老年人使用抗胆固醇药物的使用.
- 由于方法不同,需要进一步的研究,以便在研究中进行有意义的比较.
更多相关视频
06:52Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
Published on: September 30, 2020
10.4K
11:21Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
Published on: July 27, 2018
8.6K
相关概念视频
01:15Drug Dosing: Geriatric Patients
199
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
199
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
172
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
172
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
201
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
201
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
214
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
214
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
200
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
200
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
176
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
176