在行为变异中表达式的表现形式前性退化和晚期发作的精神疾病
Agnès Denève1, Marie Villain2, Cécile Bordier1
1Lille Neuroscience and Cognition, Inserm U1172, Universite de Lille, Centre Hospitalier Universitaire de Lille.
行为变异前退行症 (bvFTD) 患者表现出降低的音调范围和语音的变化,与精神病患者或健康对照不同. 这些前性变化与bvFTD中的大脑缩有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 语言学的语言学.
背景情况:
- 传统上,社会认知评估侧重于思维和情感识别.
- 数字化措施为检测异常社会互动提供了新的途径.
- 使用语音标记区分神经和精神疾病是一种新兴领域.
研究的目的:
- 为了研究行为变异前退行症 (bvFTD) 的前性变化.
- 探索这些前性变化的结构神经相关性.
- 要区分bvFTD与晚发或非典型精神疾病 (LOAPD) 和健康对照 (HCs).
主要方法:
- 分析了31名bvFTD患者,15名LOAPD患者和39名HC患者的音频录音.
- 演讲样本包括一个历史采访和一个叙事任务.
- 基本频率 (f0) 度量和基于voxel的形态测量被用于评估prosody和大脑结构.
主要成果:
- 与HC相比,bvFTD患者在两种语言任务中表现出较小的f0范围.
- 无论是bvFTD还是LOAPD组,在历史面试期间,f0变化都比HCs低.
- 在bvFTD中,减少的前与特定的额头和部大脑区域的缩相关.
结论:
- bvFTD的特点是狭窄的音程范围和减少的语调变化.
- 这些前性变化与前性网络中断有关.
- 体变化代表了bvFTD的潜在诊断标记,需要进一步调查.
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