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Updated: May 5, 2026

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
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Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

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机器学习和可解释的人工智能在肠道微生物组研究中的使用:一个范围审查

Hania Tourab, Laura Lopez-Perez, Pena Arroyo-Gallego

    IEEE journal of biomedical and health informatics
    |October 9, 2025
    PubMed
    概括

    机器学习和人工智能增强了对人类健康的肠道微生物组研究. 可解释的人工智能集成对于可靠的精准医学至关重要,尽管可重复性需要更多的关注.

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    Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
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    The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
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    Functions of the Gut Microbiota01:18

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    The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
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