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Updated: Jan 15, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

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功能和结构研究的埃斯佩拉米辛硫酶和进展向了解Enediyne核心生物合成的进步

Erome D Hankore1, Mitchell D Miller2, Abigael J Kosgei2

  • 1Pharmaceutical Sciences Department, University of Kentucky, 789 South Limestone, Lexington, Kentucky 40506, United States.

Journal of natural products
|October 9, 2025
PubMed
概括

氨酸化酶 (TEs) 从聚基化合成酶 (PKSEs) 释放聚烯前体,以产生强效的抗瘤化合物. 结构和生化研究揭示了一个关键的催化残留物,Glu68,对于聚释放和enediyne生物合成至关重要.

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Peptidoglycan Synthesis

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