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儿科患者的pT1a乳头甲状腺癌

Sin-Ting Tiffany Lai¹, Mya Bojarsky¹, Julia Baran¹

¹Division of Endocrinology and Diabetes, The Thyroid Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

European thyroid journal

|October 9, 2025

概括

偶然的乳头甲状腺癌 (iPTC) 在5.1%的小儿甲状腺切除术中被发现是因为良性疾病. 儿科iPTC与非偶发性PTC (niPTC) 不同,具有最小风险的惰性.

科学领域:

儿科内分泌学儿科内分泌学
手术瘤学手术瘤学
甲状腺癌研究研究

背景情况:

观察性研究表明,偶发性乳头甲状腺癌 (iPTC) 和非偶发性PTC (niPTC) 是成人不同的实体.
这项研究调查了为良性疾病进行甲状腺切除术的儿科患者的IPTC.

研究的目的:

为了确定为良性疾病进行甲状腺切除术的儿科患者中IPTC的发病率.
为了比较儿科患者的IPTC与niPTC的临床,组织病理学发现和结果.
评估儿科iPTC的惰性和风险概况.

主要方法:

费城儿童医院的回顾性图表审查 (2010年8月 - 2023年2月).
在甲状腺切除术后诊断出pT1a乳头甲状腺癌 (PTC) 的儿科患者的鉴定.
iPTC 和 niPTC 队列之间的临床和病原学特征的比较.

主要成果:

在5.1%的儿科甲状腺切除术中,IPTC发现了良性疾病.
与niPTC相比,iPTC显示瘤大小显著较小 (3mm与7mm相比),淋巴侵入率较低 (0%与60.5%相比),AJCC N1疾病较少 (0%与55.8%相比).
大多数iPTC (95.7%) 是低风险 (ATA儿科),而niPTC具有更高的中级/高风险分类 (14.0%). 在随访期间,没有IPTC患者表现出持续性或复发性疾病.

结论:

偶然的乳头甲状腺癌 (iPTC) 发生在5.1%的小儿甲状腺切除术中.
儿科iPTC看起来很惰,类似于成年人,具有最小的侵入性特征和低复发风险.
儿科患者的非偶然性PTC (niPTC) 显示出潜在的侵入性行为,应该被视为一个独立的实体.

关键词:

格雷夫斯的疾病.偶然发生的甲状腺癌.儿科儿科儿科儿科甲状腺癌是甲状腺癌.

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