在罗马的MSM中早期采用多西环林预防:来自参考性传播疾病诊所的见解
Maria Gabriella Donà1, Mauro Zaccarelli1, Massimo Giuliani1
1STI/HIV Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy.
International journal of STD & AIDS
|October 9, 2025
概括
多西环素暴露后预防 (Doxy-PEP) 被一些与男性发生性关系的男性 (MSM) 用来预防性传播疾病,通常没有医疗指导. 使用与高风险的性行为有关,表明需要监督策略.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 皮肤病学 皮肤病学
背景情况:
- 多西环素暴露后预防 (Doxy-PEP) 有效地预防与男性发生性关系的男性 (MSM) 和患有复发性传播感染的人的克拉米迪亚和梅毒.
- 目前CDC和IUSTI欧洲的指导方针为性传播疾病预防策略提供了信息.
研究的目的:
- 调查多西环林在意大利罗马的性传播感染/艾滋病毒中心的MSM中用于性传播感染预防的使用.
- 在这个人群中分析与多西环林预防使用相关的因素.
主要方法:
- 一个匿名的,自我管理的问卷收集了有关性行为,艾滋病毒状态,PrEP使用,性病史,物质使用和多西环林预防使用的数据.
- 使用后勤回归来确定多西环林使用与人口统计/临床因素之间的关联.
主要成果:
- 在290名注册的MSM中,9.3%的人报告使用了多克西-PEP或多克西环素暴露前预防 (PrEP),近一半的人没有接受医疗监督.
- 多西环林使用与拥有≥20个性伴侣,娱乐性勃起功能障碍药物使用和没有避孕套的交有显著联系.
结论:
- 在研究人群中,多西环林预防很少用于性传播疾病的预防,但与具有更高风险的性行为的人有关.
- 迫切需要制定国家指导方针,以解决非正式的抗生素使用问题,并促进高风险人群的监督性性传播感染预防.
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