在MOG抗体相关疾病中怀孕前,怀孕期间和怀孕后复发风险:两中心回顾性研究
Angie H Kim1, Olivia Pasquale2, Gabriela Romanow3
1NYU Multiple Sclerosis Comprehensive Care Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
概括
怀孕与患有髓寡基核糖蛋白抗体相关疾病 (MOGAD) 的妇女的复发风险非常低. 在MOGAD患者和低妊娠前复发率的患者中,产后复发风险似乎很低.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 生殖医学 生殖医学
背景情况:
- 髓寡细胞糖蛋白抗体相关疾病 (MOGAD) 是一种炎症性中枢神经系统疾病.
- 怀孕对MOGAD疾病活动的影响尚不清楚.
- 了解与怀孕相关的复发风险对于管理MOGAD至关重要.
研究的目的:
- 为了调查怀孕期间和分娩后妇女MOGAD的复发风险.
- 评估疾病修饰疗法 (DMT) 在怀孕和产后期间对MOGAD活性的影响.
主要方法:
- 对怀孕的MOGAD患者的回顾性图表审查.
- 对人口,神经,产科和治疗数据的分析.
- 计算每年复发率 (ARRs) 在怀孕前,怀孕前和产后.
主要成果:
- 在15名接受MOGAD治疗的女性中,22次怀孕期间没有复发.
- 在一个患者中观察到两次产后复发,该患者的疗程依赖于类固醇.
- 平均ARR为怀孕前的0.26,怀孕期间的0和分娩后的0.09.
- 55%的孕妇在受孕时接触DMT,59%的孕妇在分娩后继续接触DMT.
- 产科并发症发生在22%的怀孕中.
结论:
- 怀孕期间复发的风险是非常低的妇女MOGAD.
- 在MOGAD患者中,产后复发风险似乎没有升高,而怀孕前复发率较低.
- 在产后期使用DMT可能有助于降低复发率.
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