通过使用手持式拉曼光谱仪进行表面增强拉曼光谱检测假冒药品中的芬太尼类型
Sevde Dogruer Erkok1, Martin M Kimani2, Adam Lanzarotta2
1Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
Forensic science international
|October 9, 2025
概括
表面增强拉曼光谱 (SERS) 为检测假冒药片中的芬太尼及其类型提供了一种高度敏感的方法. 这种便携式技术实现了100%的灵敏度,帮助执法部门识别危险物质.
科学领域:
- 分析化学 分析化学
- 法医科学 法医科学 法医科学
- 频谱学是一种光谱学.
背景情况:
- 芬太尼及其类似物是美国药物过量死亡的主要原因,假冒药丸构成重大威胁.
- 执法机构正在扣押数百万个含芬太尼的假药,突出了快速检测方法的必要性.
- 便携式分析技术对于实地识别非法物质至关重要.
研究的目的:
- 为了证明表面增强拉曼光谱 (SERS) 在假冒药片中假定检测芬太尼及其类型的有效性.
- 为了评估不同激光波长 (785nm和1064nm) 的便携式拉曼仪器的性能,用于SERS分析.
- 评估SERS在查获假冒药片中识别芬太尼和芬太尼类型的敏感性和选择性.
主要方法:
- 使用了两个便携式拉曼光谱仪 (785nm和1064nm激光器).
- 使用商业银纳米粒子和合成的金/银纳米星来增强表面.
- 分析了包含芬太尼或其类型的14个被扣押的假冒药片.
主要成果:
- 在100%分析的假冒药片中,SERS正确识别了芬太尼或芬太尼类型.
- 与785nm激光相比,1064nm激光配置提供了更清晰,更一致的光谱数据.
- 在用于SERS的纳米粒子类型之间没有观察到敏感度的显著差异.
结论:
- SERS是一种高度敏感和有选择性的技术,用于假冒药片中假定检测芬太尼和芬太尼类似物.
- 便携式拉曼光谱,特别是使用1064nm激光器,对基于现场的法医分析有很大的前景.
- 这种方法可以显著帮助执法部门识别和拦截危险的假冒药品供应.
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