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Updated: Jan 15, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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评估含有Zn-Ionophore和聚合抑制部分的双重功能分子,用于突变的p53蛋白重新激活

Kalvin Kwan1, Ashkan Saffari1, Lauryn Grcic1

  • 1Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

Journal of inorganic biochemistry
|October 9, 2025
PubMed
概括

新的连接体显示出恢复突变p53蛋白的功能,这是癌症的关键因素. 这些化合物结合并抑制蛋白质聚合,没有显著的毒性,为癌症治疗提供了潜在的新途径.

关键词:
细胞毒性 细胞毒性离子体离子体蛋白质聚合蛋白质的聚合.可以在中找到.在p53蛋白质中,p53蛋白质是

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