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在deneddylation抑制后,CRL4调解了DDB1的自身化

Yeong-Mu Kim1, Jae-Hyun Jo1, Dong-Kyu Kim1

  • 1Department of Biochemistry, Chungbuk National University, Cheongju, 28644, South Korea; Department of Biological Sciences and Biotechnology, Chungbuk National University, Cheongju, 28644, South Korea.

Biochemical and biophysical research communications
|October 9, 2025
PubMed
概括

抑制脱脱化通过CRL4依赖的自化破坏DDB1的稳定,损害DNA复制并增强对p97/VCP抑制剂的脆弱性. 这揭示了CRL4和p97/VCP之间的合成相互作用.

关键词:
在CRL4自行除中.这是一种CSN5抑制剂.DDB1 DDB1 DDB1 在线播放RepID RepID 的意思就是说.这是一种p97/VCP抑制剂.

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