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精子胺通过改善线粒体健康状况来增强巨细胞的抗炎和再生功能

Rui Liu¹, Lijuan Cao¹, Yipeng Zhou²

¹The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|October 9, 2025

概括

精子胺补充剂可以增强巨细胞的功能,通过改善线粒体健康和促进抗炎反应来减少肝纤维化. 这种新陈代谢重编程为纤维性疾病提供了一种新的治疗策略.

科学领域:

免疫学免疫学免疫学
代谢途径代谢途径
肝脏疾病研究肝脏疾病研究

背景情况:

肝纤维化是慢性肝损伤的结果,巨细胞的可塑性起着关键作用.
亲纤维性巨细胞功能的代谢调节和治疗向仍然未得到充分研究.

研究的目的:

调查精素对巨细胞功能的影响及其在肝纤维化中的治疗潜力.
探索精氨酸对巨细胞的影响的代谢基础.

主要方法:

对慢性肝病数据集和scRNA-seq数据的分析,以检查肝细胞巨细胞中的精子素代谢.
在小鼠中用精氨酸治疗四化碳 (CCl4) 诱导的肝纤维化.
利用宏细胞特异性PGC1α淘汰小鼠来评估线粒体适应性的作用.
通过采养将精子治疗的巨细胞 (SPDMs) 转移给纤维化小鼠.

主要成果:

在患病肝脏的巨细胞中观察到受调节的多胺代谢,特别是精子胺.
精子胺治疗通过促进抗炎和促溶性巨细胞功能,保护了CCl4诱导的肝纤维化.
SPDMs表现出增强的线粒体质量,氧化酸化和脂肪酸代谢,依赖于PGC1α.
采用SPDM转移显著降低了肝纤维化,在PGC1α缺乏的小鼠中影响受到损害.

结论:

肝脏巨细胞中的精子素代谢失调有助于慢性肝病.
精子胺通过通过PGC1α增强巨细胞线粒体适应性来发挥抗纤维性作用.
通过精子胺介导的代谢重编程来准巨细胞的可塑性,为纤维性疾病提供了一个新的治疗途径.

关键词:

肝脏纤维化肝脏纤维化巨细胞是一个巨细胞.代谢过程中的代谢.过氧体增殖器激活的受体-γ联合激活剂-1αα.精子胺是什么精子胺是什么乙醇-可阿脱酸酶 1 的作用.

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