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罗素通过调节肠道微生物群衍生的3-烯酸和AhR/IL-22/STAT-3轴来缓解沙门氏菌感染

Linlin Ding¹, Qingjie Li², Kaige Qi¹

¹State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|October 9, 2025

概括

罗素通过改善肠道健康和微生物群来保护小免受沙门氏菌的感染. 这种天然化合物,特别是其代谢物3-PPA,增强肠道屏障功能,减少炎症.

科学领域:

动物科学动物科学
微生物学微生物学
免疫学免疫学免疫学

背景情况:

沙门氏杆菌 (S. pullorum) 感染导致家禽的生长受到损害,造成了巨大的经济损失.
罗是一种天然的黄类化合物,在调节肠道微生物群方面具有潜力,对胃肠道健康有益.
罗对S. pullorum的特定保护机制在很大程度上是未知的.

研究的目的:

为了研究弗洛雷丁在小中对S. pullorum感染的保护作用.
阐明底层机制,重点关注肠道微生物群调节.
为了确定关键的微生物和代谢因素,涉及到弗洛雷丁的疗效.

主要方法:

组织病理学 (H&E染色),基因表达 (RT-qPCR) 和蛋白质分析 (ELISA) 评估了的健康状况.
16S rRNA测序和非向的代谢学发现了微生物和代谢物变化.
便微生物种移植 (FMT) 和代谢物补充实验证实了这种机制.

主要成果:

罗提升了的生长,改善了肠道屏障的完整性,并在S. pullorum感染期间抑制了炎症.
来自flouretin治疗的捐赠者的便微生物群移植复制了这些好处.
洛增加了诸如Faecalibacterium之类的有益细菌及其代谢物3-烯酸 (3-PPA) 的含量.
3-PPA补充剂通过AhR/IL-22/STAT-3通路减轻了S. pullorum引起的损伤和炎症.

结论:

罗在小中显示出S. pullorum感染的治疗潜力.
肠道微生物群的调节,特别是便细菌的丰富和3-PPA的产生,是关键机制.
3-PPA通过AhR/IL-22/STAT-3信号轴作用,以保护肠道.

关键词:

一个漂亮的小.我们的肠道微生物群.罗氨酸是一种素.沙门氏菌 (Salmonella pullorum) 是一种有毒的植物.

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