跨王国的脂质信使维持肠道和
1Key Laboratory of Multicellular Systems, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Cell host & microbe
|October 9, 2025
概括
不和脂肪酸在炎症期间在肠道中积累,并对肠道细菌造成伤害. 细菌酶将这些脂肪酸转化为无害的形式,抑制炎症并保持肠道平衡.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道免疫激活导致不和长链脂肪酸 (uLCFA) 的积累.
- 这些uLCFA对有益的共生细菌有毒,可能会破坏肠道微生物群.
- 布劳蒂亚产物被确定为一种对uLCFA毒性敏感的共生物.
研究的目的:
- 研究在免疫激活期间肠道中ULCFA的作用.
- 了解共生细菌与uLCFA相互作用的机制.
- 探索肠道细菌如何通过代谢途径调节宿主免疫反应.
主要方法:
- 在免疫激活期间分析肠道微生物组成和代谢物概况.
- 在体外研究评估ULCFA对Blautia产生的毒性.
- 参与ULCFA代谢的细菌酶的识别和表征.
主要成果:
- 发现不和长链脂肪酸 (uLCFA) 在免疫激活过程中会在肠道中积聚.
- 蓝产物,一个关键的共生动物,表现出对uLCFA毒性的敏感性.
- 一种与共生体编码的酶,油酸酸酶,已被证明可以将有毒的ulCFA转化为无毒的氧脂肪酸 (FA).
结论:
- 肠道细菌拥有可以排毒有害代谢物如ULCFA的机制.
- 通过细菌油酸酸酶将ULCFA转化为氧FA,可以抑制促炎性T细胞.
- 这种代谢交叉对维持肠道免疫静止和共生关系至关重要.
更多相关视频
07:25Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
Published on: December 9, 2022
2.0K
06:14The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion
Published on: November 30, 2022
3.2K
相关概念视频
Lipid Digestion
98.7K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
98.7K
Biosynthesis of Lipids
527
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
527
Lipid-derived Compounds in the Human Body
6.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.2K
Lipid Absorption
2.4K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
2.4K
Membrane Fluidity
14.5K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
14.5K
Membrane Fluidity
172.8K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
172.8K
