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Updated: Jan 15, 2026

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在塞内加尔的急性发烧性黄患者中,E型肝炎的发病率,2008-2020年
Elisabeth Thérèse Faye1, Arfang Diamanka2, Sophie Kang3
1WHO Collaborating Center for Arbovirus and Viral Hemorrhagic Fevers, Virology Pole, Institut Pasteur de Dakar, Dakar, Senegal.
The American journal of tropical medicine and hygiene
|October 9, 2025
概括
在塞内加尔,肝炎E病毒 (HEV) 影响了14%的急性发烧黄患者. 国家黄热病监测计划有效地确定了HEV基因型2b,这表明疫情的风险很高.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肝炎E病毒 (HEV) 在全球范围内构成了重大公共卫生挑战.
- 在塞内加尔已经记录了HEV疫情,但其整体负担仍然不太清楚.
- 塞内加尔对HEV的现有监测是有限的,没有专门的计划.
研究的目的:
- 确定塞内加尔急性发烧黄患者中HEV的流行率.
- 为了描述研究人口中循环的HEV基因型.
- 评估国家黄热病监测计划对HEV检测的有用性.
主要方法:
- 对2008年至2020年期间收集的2387名黄患者样本的回顾性分析.
- 使用IgM/IgG ELISA和RT-PCR进行HEV检测.
- 对RT-PCR阳性样本进行测序和遗传学分析.
主要成果:
- 在患有急性发烧黄的患者中,总体HEV患病率为14%.
- 在29个IgM阳性样本中,RT-PCR检测证实了74个IgM阳性样本.
- 遗传学分析确定了HEV基因型2b,通常与非洲疫情有关.
结论:
- 在塞内加尔,HEV是本土的,在发烧性黄患者中具有显著的流行率.
- 这些发现证实了2014年凯杜古爆发的情况,并表明HEV在其他地区的传播.
- 黄热病监测基础设施为塞内加尔和可能其他国家的综合HEV监测提供了一个可行的平台.
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