新兴耐药性指数:追踪对新抗生素的早期耐药性
Jacopo Garlasco1, Fabiana Arieti1, Matteo Morra1
1Department of Diagnostics and Public Health, Infectious Diseases Division, University of Verona, Verona, Italy.
The Lancet. Infectious diseases
|October 9, 2025
概括
一个新的新兴耐药性指数 (ERI) 量化了对新抗生素的耐药性. 欧洲抗生素研究报告显示,对格兰氏阴性抗生素的耐药性发展迅速,强调需要更好的监测和政策.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗微生物药物耐药性 (AMR) 构成了重大的临床挑战,新抗生素的流量下降加剧了这一挑战.
- 标准化工具对于监测对新型抗微生物药物的耐药性发展至关重要.
研究的目的:
- 引入和评估新兴耐药性指数 (ERI),这是一个用于跟踪新抗生素耐药性的新型定量工具.
- 评估针对格拉姆阴性细菌的新开发抗生素的耐药性趋势.
主要方法:
- 该ERI的开发包括AMR比例,监测系统的可用性,耐药性检测的时间和疫情数据.
- 从文献和38个监测系统中收集了13种新抗生素的数据,这些数据来自欧盟国家,EFTA国家和英国的38个监测系统.
主要成果:
- 对所有新的克阴性向抗生素观察到快速的耐药性发展.
- 伊米-relebactam和 cefiderocol表现出特别高的 ERI 值,这表明耐药性迅速出现.
- 较旧的β-乳酸胺与新抑制剂的组合显示出对快速抗药性发展的高度倾向.
结论:
- ERI提供了一种定量和动态的方法来监测抗菌素耐药性趋势.
- 欧洲抗生素研究所可以加强监测工作,为抗生素政策提供信息,并指导抗生素研究和开发优先事项.
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