NCCN指南® 洞察力:B细胞淋巴瘤 3.202525 洞察力
Andrew D Zelenetz1, Leo I Gordon2, Jeremy S Abramson3
11Memorial Sloan Kettering Cancer Center.
Journal of the National Comprehensive Cancer Network : JNCCN
|October 9, 2025
概括
新型向疗法,包括双特异性抗体和布鲁顿氨酸激酶 (BTK) 抑制剂,正在改变B细胞淋巴瘤治疗. 这些进展对卵泡淋巴瘤 (FL),地幔细胞淋巴瘤 (MCL) 和扩散大B细胞淋巴瘤 (DLBCL) 有希望.
科学领域:
- 血液学和瘤学研究
- 临床治疗学 临床治疗学
- 免疫治疗是一种免疫疗法.
背景情况:
- 针对B细胞淋巴瘤的治疗已经取得了重大进展,最近批准了新的向疗法.
- 根据新出现的治疗选择,正在重新评估既定的治疗方案.
研究的目的:
- 为突出国家综合癌症网络 (NCCN) 关于B细胞淋巴瘤的指南的重大更新.
- 审查针对特定B细胞淋巴瘤亚型的新型向疗法的疗效,包括毛囊淋巴瘤 (FL),地幔细胞淋巴瘤 (MCL) 和扩散性大B细胞淋巴瘤 (DLBCL).
主要方法:
- 审查最近的临床试验数据和针对B细胞淋巴瘤的向治疗的监管批准.
- 对NCCN指南更新的分析与FL,MCL和DLBCL治疗策略有关.
- 专注于CD3 × CD20双特异性抗体,CD19定向的单克隆抗体,抗体-药物结合物和布鲁顿氨酸激酶 (BTK) 抑制剂.
主要成果:
- CD3 × CD20双特异性抗体和针对CD19的疗法在复发性/耐药性卵泡淋巴瘤 (FL) 中显示出有效性.
- 基于布鲁顿氨酸激酶 (BTK) 抑制剂的疗法在TP53突变的经典地幔细胞淋巴瘤 (MCL) 中显示出有效性.
- 在化疗免疫治疗中添加CD3 × CD20双特异性抗体可能会改善复发性/耐药性扩散性大B细胞淋巴瘤 (DLBCL) 的结果.
结论:
- 新型向疗法代表了管理B细胞淋巴瘤的范式转变.
- 更新的NCCN指南反映了这些新药物对FL,MCL和DLBCL的整合.
- 持续的研究和临床试验对于进一步完善这些血液性恶性瘤的治疗策略至关重要.
相关概念视频
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
B Cell Activation and Differentiation
16.0K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
16.0K
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Primary Lymphoid Organs
14.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.6K
Lymphoid Cells and Tissues
2.9K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.9K
Cytotoxic T Cells-mediated Immune Response
6.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.5K


