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皮肤癌化学预防:一个概述
Mariana Bastos1, Lucília Saraiva2, Ana Camila Marques1
1UCIBIO, Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; Associate Laboratory i4HB, Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Drug discovery today
|October 9, 2025
概括
皮肤癌率的上升需要新的预防策略. 本综述探讨了NSAIDs和抗氧化剂等化学预防剂,显示了黑色素瘤预防的前景,但需要临床验证.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 预防医学 预防医学
背景情况:
- 全球黑色素瘤和非黑色素瘤皮肤癌 (NMSCs) 的发生率正在增加,主要是由于紫外线辐射暴露.
- 黑色素瘤由于其侵略性和晚期诊断和复发的倾向, presents显著的治疗挑战.
- 目前的防晒提供有限的保护,强调了需要替代性皮肤癌预防方法.
研究的目的:
- 审查化学预防疗法在缓解皮肤致癌的潜力.
- 讨论各种药物的有效性,包括NSAIDs,他类药物,抗氧化剂和维生素,以抑制皮肤癌的发展.
- 突出黑色素瘤预防策略的临床前发现和临床验证之间的差距.
主要方法:
- 对皮肤癌化学预防剂的临床前和临床研究的文献综述.
- 在皮肤致癌过程中,这些药物准的分子通路的分析.
- 关于非类固醇抗炎药物,他类药物,抗氧化剂和维生素的影响的综合证据.
主要成果:
- 合成和天然的化学预防剂在抑制不同阶段的皮肤癌方面表现出潜在的潜力.
- 临床前数据表明,NSAIDs,他类药物,抗氧化剂和维生素可以预防或延迟黑色素瘤的发展.
- 现有有限的临床数据证实了这些药物的有效性和长期安全性.
结论:
- 化疗预防是管理日益增长的皮肤癌,特别是黑色素瘤的有希望的途径.
- 进一步严格的临床试验对于确定黑色素瘤化学预防剂的疗效和安全性至关重要.
- 将有希望的临床前发现转化为有效的临床策略仍然是预防皮肤癌的关键挑战.
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