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Updated: Jan 15, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
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域间循环调节了TEM类型扩展光谱β-乳糖酶抗生素耐药活性的构造动态

Tsz-Fung Wong1, Pui-Kin So2, Wai-Po Kong1

  • 1State Key Laboratory of Chemical Biology and Drug Discovery, Food Safety and Technology Research Centre, Research Centre for Chinese Medicine Innovation, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, the Hong Kong Special Administrative Region of China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), and Shenzhen Key Laboratory of Food Biological Safety Control, Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China.

Journal of molecular biology
|October 9, 2025
PubMed
概括

在TEM型扩展谱β-乳酸酶 (ESBLs) 中的突变改变了酶动态,影响了抗生素耐药性. 了解这些形状变化是打击细菌耐药性和开发新药的关键.

关键词:
抗生素耐药性 抗生素耐药性构造动力学 构造动力学扩展光谱β-乳酸酶酶的作用./交换的交换方式质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量

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