肺移植后第一年生活质量和肺功能变化的时间:多中心前性队列研究
Wayne M Tsuang1, Megan L Neely2, Lianne G Singer3
1Department of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio.
概括
肺移植接受者在第一年经历了改善的肺功能和生活质量 (QoL). 然而,最佳的QoL得分通常发生在峰值肺功能 (FEV1) 之后,时间因患者因素而异.
科学领域:
- 肺部病理学 肺部病理学
- 移植手术 移植手术
- 健康 结果 研究 研究 结果
背景情况:
- 肺移植 (LT) 改善了肺功能和生活质量 (QoL).
- 螺旋测量改进与LT后的QoL增长之间的时间关系需要澄清.
研究的目的:
- 为了确定QoL的改善是否与肺移植后第一年内的螺旋计 (FEV1) 评估相吻合.
- 分析峰值QoL得分是否发生在峰值FEV1.1之前,同时发生或之后.
主要方法:
- 对702名来自"器官移植20项临床试验"的LT接受者的观察性研究.
- 强迫呼气量在1秒内 (FEV1) 和QOL (圣乔治呼吸问卷,SF-36) 在LT后1,3,6,9和12个月的长度评估.
- 对最佳QoL得分相对于最佳FEV1.1的时间进行分析.
主要成果:
- 大多数患者 (55.7%) 在最佳FEV1.1后达到最佳呼吸率 (SGRQ).
- 同样,48.6%的人在最佳FEV1.1之后达到最佳体力QOL (SF-36).
- 诸如单个LT,年龄超过65岁,男性性别和非囊性肺病诊断等因素与最佳FEV1.1后的最佳QoL相关.
结论:
- 螺旋测量和QoL领域在LT后得到了改善,但并不总是同时进行.
- 几乎一半的患者在FEV1峰值后达到呼吸和身体QOL峰值,时间受受受体特征的影响.
- 调查结果强调,对于全面了解LT后恢复,对螺旋计和QoL的监测的重要性.
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