在没有明显的心血管疾病的情况下,早发性心房动的长期预后
Anders Holt1, Jarl Emanuel Strange1, Gunnar H Gislason2
1Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Heart rhythm
|October 9, 2025
概括
在年轻的,其他健康的个体中,早发性心房动 (AF) 显著增加了中风,心力衰竭 (HF) 和死亡的长期风险. 这一发现突显了AF作为未来心血管并发症的关键标志物,特别是HF.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在没有先前心血管疾病的个体中,早发性心房 (AF) 的长期预后影响仍然不清楚.
- 早期发作的AF影响年轻人,需要了解其相关风险.
研究的目的:
- 调查早期发作的AF诊断的患者中风,心力衰竭 (HF) 和死亡的长期风险.
- 将这些风险与没有AF的匹配对照人群进行比较.
主要方法:
- 利用全国范围的登记册来识别1999-2023年间首次AF诊断的成年患者 (18-45岁),不包括之前患有心血管疾病的患者.
- 将AF患者与没有AF的一般人群中的对照组进行匹配.
- 估计的长期绝对风险和标准化风险比率 (RRs) 对于中风,HF和死亡.
主要成果:
- 在7632名早期发作的AF患者中,20年风险为中风6.89%,高血压6.45%,死亡7.10%.
- 与对照组相比,AF患者面临显著增加的标准化风险:中风的RR为2.00,高血压为4.33,死亡为1.37.
结论:
- 在没有心血管并发症的个体中,早期发病的AF与长期心血管风险的增加有关.
- 一个特别值得注意的发现是心力衰竭 (HF) 的风险增加了4到5倍.
- 早期发作的AF应该被认为是年轻的,其他健康患者未来心肌病和HF发展的重要指标.
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