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在早产新生儿中对单次和多次延迟动脉旋转标记MRI进行比较评估

Yeva Prysiazhniuk¹, Sasha Alexander², Rui Duarte Armindo³

¹Department of Pathophysiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Radiology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

|October 9, 2025

概括

多延迟动脉旋转标记 (ASL) MRI为早产新生儿提供了优越的图像质量,使得可以准确评估大脑血流 (CBF) 和动脉过渡时间 (ATT). 这种技术对于理解新生儿大脑发育和损伤至关重要.

科学领域:

新生儿神经成像新生儿神经成像
医学成像技术医学成像技术
脑血管生理学脑血管生理学

背景情况:

过早出生的新生儿由于大脑血流 (CBF) 改变而容易受到脑损伤.
高质量的MRI在新生儿神经成像中具有挑战性.
动脉旋转标记 (ASL) MRI提供了非侵入性的CBF量化,但需要在新生儿身上进行进一步的研究.

研究的目的:

评估ASLMRI在非镇静早产新生儿中的可行性.
为了比较单延迟和多延迟ASL之间的图像质量和血液动力学测量.
评估性别和年龄对早产新生儿CBF和ATT的影响.

主要方法:

48名早产新生儿接受了T1w,T2w和单次和多次延迟ASL扫描.
图像质量被评估并通过各种方式进行比较.
皮层CBF和动脉传输时间 (ATT) 被量化并分析了与性别和年龄的关联.

主要成果:

多延迟ASL产生了最高可接受的图像质量.
单次延迟的ASL显示皮质CBF明显低于多次延迟的ASL.
观察到CBF和ATT的性别和年龄相关差异,突出显示出血液动力学变异.

结论:

多延迟ASL是新生儿神经成像的首选技术,因为图像质量优越和血液动力学评估.
观察到的血液动力学变化强调了区分ATT和CBF的技术的需要.
ASL质量与结构扫描相当,支持其在新生儿成像中的临床采用.

关键词:

在ASL中,ASL是ASL.动脉过境时间动脉过境时间大脑的血液流动.perfusion perfusion 输液磁力共振成像磁力共振成像过早出生的新生儿

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