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使用TIPS技术作为一种可能的急性吸入毒性评估方法

Dina Mourad Saleh^1,2,3, Omnia Hosny Mohamed Ahmed^3,4, David B Alexander³

¹Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Journal of applied toxicology : JAT

|October 9, 2025

概括

气管内肺内喷射 (TIPS) 为急性吸入毒性测试提供了一个可行的替代方案,不需要专门的设备. 这种方法与许多化学品的已确定的LC50值有很好的一致性,有助于更广泛的毒性评估.

科学领域:

毒理学毒理学毒理学
药理学药理学是指药理学的学科.
化学安全化学安全

背景情况:

吸入急性毒性研究对化学品安全至关重要,但需要专门的设备,限制其可访问性.
由于这些限制,大量化学品缺乏被评估的吸入毒性.

研究的目的:

调查内肺内喷雾 (TIPS) 作为一种更容易获得的急性吸入毒性测试方法.
通过将其结果与已确定的吸入毒性数据进行比较,评估TIPS的有效性.

主要方法:

12种化学物质被稀释在生理盐水中,并用TIPS方法给试验动物.
通过TIPS获得的LD50值被转换为LC50值,以与报告的吸入LC50值进行比较.

主要成果:

对于11种水溶性化学物质中的9种,TIPS表现出与报告中的LC50值达成良好一致.
对于两种水溶性化学物质和一种水不溶性化学物质 (烯) 观察到差异,这表明了潜在的限制.

结论:

由于其可访问性,TIPS显示出作为一种广泛适用的急性吸入毒性测试方法的巨大潜力.
需要进一步的研究来确定TIPS的化学适用范围,特别是对于不溶于水的化合物.

关键词:

A549 急性毒性模型急性吸入性毒性有毒性内内肺内喷雾内内肺内喷雾

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