在非小细胞肺癌中下一代放射性测序:一种替代模型来预测来自[18F]FDG PET/CT的突变
Lavinia Monaco1, Cinzia Crivellaro1, Elisabetta De Bernardi2,3
1Nuclear Medicine Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Lombardy, Italy.
Therapeutic advances in respiratory disease
|October 9, 2025
概括
[18F]FDG PET/CT放射学显示了在非小细胞肺癌 (NSCLC) 中预测KRAS突变的潜力. 一个纹理复杂性特征 (FBS_glcm_MCC) 与KRAS突变状态有关,提供了一个非侵入性成像生物标志物.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 生物标志物发现发现
背景情况:
- 非小细胞肺癌 (NSCLC) 是全球癌症死亡的主要原因.
- 针对EGFR和KRAS突变的向疗法可以改善NSCLC的结果,但基因分析并不总是可获得的.
- 放射学从医疗图像中提取定量特征,如[18F]FDG PET/CT,提供一种非侵入性的方法来评估瘤异质性并确定预测生物标志物.
研究的目的:
- 评估[18F]FDG PET/CT放射性特征在预测NSCLC突变中的潜力.
- 在NSCLC患者中确定EGFR和KRAS突变状态的非侵入性成像生物标志物.
主要方法:
- 对105名NSCLC患者的回顾性分析证实了组织学,下一代测序 (NGS) 和基线[18F]FDG PET/CT扫描.
- 从PET图像中提取放射性特征 (766个瘤),使用Pyradiomics和符合IBSI的算法.
- 用LASSO逻辑回归来进行突变关联特征选择,并对来自两个不同的PET/CT扫描仪的独立数据集进行验证.
主要成果:
- 在评估的数据集中,没有放射性特征与EGFR突变显著相关.
- 一个特定的放射性特征,FBS_glcm_MCC (测量图像纹理复杂性),与KRAS突变状态显著相关 (AUC=0.68,p=0.04).
- 这种基于纹理的特征在独立验证队列中证明了KRAS突变的预测价值.
结论:
- 初步发现表明[18F]FDG PET放射学可能作为NSCLC基因分析的非侵入性替代品,特别是在KRAS突变中.
- 已识别的放射性特征 (FBS_glcm_MCC) 是一个有前景的预测生物标志物.
- 需要在更大,多样化的患者队伍中进一步验证,以确认这些发现和临床实用性.
关键词:
欧洲农业基金会 (EGFR) 是一个基金.克拉斯 (Kras) 是一个国家.国家储备系统 (NGS)在NSCLCLC中,我们可以看到.[18F]FDG PET/CT PET/CT PET/CT/CT/CT [18F]FDG PET/CT/CT PET/CT/CT [18F]FDG PET/CT/CT肺癌是一种肺癌.无线电学 (radiomics) 是一种无线电学.更多相关视频
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
11.5K
07:59Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
1.6K
相关概念视频
01:29Positron Emission Tomography
6.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.9K
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
403
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
403