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Updated: Jan 15, 2026

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基于机理数据的多尺度定量系统药理学建模框架使CAR-T治疗在实体瘤中的临床转化和疗效评估成为可能

Siyuan Yang1, Wenjie Wang2, Qi Rao1

  • 1School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China.

Journal for immunotherapy of cancer
|October 9, 2025
PubMed
概括

定量系统药理 (QSP) 模型可以改善固体瘤的仿真抗原受体 (CAR) -T细胞疗法. 这种方法结合了生物学因素来预测CAR-T细胞的行为和患者的反应,有助于临床翻译.

关键词:
收养细胞疗法 - ACT化学抗原受体 - - CAR药学动力学 - - PD - - 药学动力学固体瘤是一个固体瘤.一个T细胞细胞.

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