肝细胞癌中WNT-β-catenin信号传递:从测试台到临床试验

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Updated: Jan 15, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Published on: September 12, 2019

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Brandon M Lehrich1,2,3,4, Satdarshan P Monga5,6,7,8

  • 1Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Nature reviews. Gastroenterology & hepatology
|October 9, 2025
PubMed
概括

在肝细胞癌 (HCC) 中WNT-β-catenin的激活创造了一个独特的瘤免疫微环境 (TIME) 和代谢特征. 了解这些因素对于开发针对HCC患者的向精确疗法至关重要.

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