用于对pH响应性结肠向药物输送的氧合碳微球的制备和表征
Mengcheng Wei1, Danlin Zeng1, Xiaoling Zhao1
1The State Key Laboratory of Refractories and Metallurgy, Hubei Key Laboratory of Coal Conversion and New Carbon Material, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China.
ACS applied materials & interfaces
|October 9, 2025
概括
大麻粉被用来创建用于药物输送的新型微球. 这些聚烯酸涂层的阿司匹林微球显示出有希望的向输送,并具有抗菌性质.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 开发有效的药物输送系统对于改善治疗结果至关重要.
- 基于微球的系统为控制和有针对性的药物释放提供了潜力.
- 大麻粉为生物材料合成提供了可持续和生物相容的来源.
研究的目的:
- 为了合成和表征使用麻豆粉的聚烯酸涂层阿司匹林/氨基-N合碳微球 (P-ASA@ANMCs).
- 评估合成的微球的药物载荷能力,细胞毒性和抗菌活性.
- 研究P-ASA@ANMCs.s的pH响应性,结肠向性和持续释放性特性.
主要方法:
- 用水热,氨化和静电涂层方法用于微球合成.
- 描述技术包括SEM,FTIR,XRD,拉曼光谱和XPS.
- 在体外研究包括细胞实验和对大肠杆菌和金黄色葡萄球菌的抗菌试验.
主要成果:
- 合成的微球表现出均的球形形态 (∼1μm) 和高药物载荷能力.
- P-ASA@ANMCs对两种测试的细菌菌株都表现出显著的抗菌活性.
- 微球显示了pH响应,结肠向,持续释放的特征.
结论:
- 麻粉衍生的微球显示生物医学应用潜力.
- P-ASA@ANMCs对于pH响应的结肠向药物递送是有效的.
- 开发的微球为增强药物输送和抗微生物应用提供了一个有希望的平台.
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