周围血液细胞分析衍生的炎症参数在预测恶性十二指肠狭窄症中的作用
Palidanguli Pata'er1, Shanshan Liu1, Jiawei Chen1
1Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China.
周围血液的炎症标志物可以帮助区分良性和恶性十二指肠狭窄症. 中性粒细胞与淋巴细胞的比率 (NLR) 显示出恶性十二指肠狭窄症的显著预测价值.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 由于解剖学复杂性和活检局限性,十二指管狭窄的诊断具有挑战性.
- 区分良性和恶性十二指甲管狭窄症需要改进的诊断工具.
研究的目的:
- 评估外周血液炎症生物标志物的潜力,以区分良性和恶性十二指肠狭窄症.
- 为了确定可靠和具有成本效益的生物标志物用于十二指肠狭窄的诊断.
主要方法:
- 对140名患有十二指肠狭窄症的患者的临床数据和周围血液细胞计数的回顾性分析.
- 根据病理学分析,患者被分为良性和恶性十二指管狭窄症组.
- 分析了包括NLR,PLR和LMR在内的关键炎症比率.
主要成果:
- 与良性病例相比,恶性十二指管狭窄症患者的NLR和PLR显著更高,LMR较低.
- 增加年龄,NLR和AST被确定为恶性十二指肠狭窄症的独立风险因素.
- 3.42的NLR值显示出高灵敏度 (80.3%) 和特异性 (91.1%) 预测恶性瘤.
结论:
- 周围血液衍生的炎症生物标志物,特别是NLR,是恶性十二指肠狭窄的有价值预测因素.
- NLR提供了一种有前途的非侵入性方法,可以提高十二指甲管狭窄的诊断准确度.
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