肠道微生物群与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的关联:一个病例控制研究
Pejman Rohani1, Shima Shojaie1, Ali Nikparast2
1Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
BMC pediatrics
|October 9, 2025
概括
肠道微生物群的变化,包括较低的Coprococcus丰度,与肥胖儿童的代谢功能障碍相关的脂肪性肝病 (MASLD) 有关. 普雷沃特拉细菌与肝酶有积极的相关性,这表明它在MASLD病变发生过程中发挥了作用.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物组研究 微生物组研究
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是儿童和青少年日益关注的问题.
- 肠道微生物群失生症越来越多地与MASLD的发病有关.
- 这项研究研究了超重/肥胖的伊朗儿科MASLD患者的肠道微生物群.
研究的目的:
- 探索肠道微生物组成和超重和肥胖的伊朗儿童和青少年中MASLD之间的关联.
- 为了确定不同于MASLD病例和对照病例的特定细菌种群.
- 为了将肠道微生物群的个人资料与临床和生化参数相关联.
主要方法:
- 病例对照研究涉及33例MASLD病例和33例对照 (年龄为136.82个月,平均BMI Z-score为3.05).
- 通过肝脏超声波和胃肠科医生评估确认了MASLD诊断.
- 使用实时PCR分析肠道微生物群;收集代谢,人体测量和饮食数据.
主要成果:
- 在MASLD群体中观察到的Coprococcus属的丰度较低.
- 原始模型中Coprococcus和MASLD几率之间的反相关性 (OR=0.87-0.81),但没有完全调整.
- 科普罗科克与ALT负相关; 普雷沃特拉与ALT和AST正相关.
结论:
- 儿科MASLD和对照组之间存在显著的肠道微生物群差异.
- 减少了SCFA产生细菌 (如Coprococcus) 和增加了促炎性细菌.
- 这些发现表明肠道微生物群在MASLD发展中的潜在作用,需要在更大的队列中进一步调查.
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