在第一发精神分裂症中,亚区域杏仁体功能连接异常和无意识障碍
Qijie Kuang1,2,3, Sumiao Zhou1,2,3, Guangxing Deng1,2,3
1Department of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, 36 Mingxin Road, Liwan District, Guangzhou, 510370, China.
BMC psychiatry
|October 9, 2025
概括
第一次精神分裂症患者表现出桃体功能连接 (FC) 发生变化,与无情相关. 这种神经生物学标志物可能独立于一般临床症状,表明杏仁核皮质与皮质失联.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 在精神分裂症中报告了异常的杏仁体功能连接 (FC).
- 大多数先前的研究都将杏仁体视为一个单一的结构.
- 这项研究调查了桃体亚区域FC和第一个发作精神分裂症 (FES) 的无.
研究的目的:
- 探索桃体亚区域功能连接 (FC) 和第一个发作精神分裂症 (FES) 患者的无意识之间的关联.
主要方法:
- 休息状态的fMRI在31名FES患者和33名健康对照 (HC) 中进行.
- 临床症状使用积极和消极综合征量表 (PANSS) 进行评估;无情感通过Snaith-Hamilton快乐量表 (SHAPS) 进行评估.
- 进行了杏仁体子区域的全脑FC分析,随后进行了群组比较和对应性分析,以无性得分为准.
主要成果:
- 与HC相比,FES患者在杏仁体子区域和皮质区域之间显著减少了FC.
- 无症的严重程度与中枢中枢 (CM) 杏仁体亚区域的改变FC正相关,特别是补充运动区域 (SMA) 和偏中心叶 (PLG).
- 在对临床症状严重程度进行调整后,右AMY_CM与右SMA FC和无症之间的关联仍然显著 (r=0.46,P=0.02).
结论:
- FES患者在杏仁体子区域和皮质区域之间表现出被破坏的FC,其特定模式与无情相关.
- 厌倦症可能与神经生物学标志物有关,独立于一般临床症状.
- 研究结果表明,在与精神分裂症相关的无神经症中,杏仁核皮质失联.
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