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Updated: Jan 15, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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PD-L1调节c-MET酸化,并有助于EGFR突变NSCLC中MET依赖性对奥西默提尼布的抵抗

Chia-Chi Hsu1,2, Derek De-Rui Huang1,3,4, Wei-Hsun Hsu1,2

  • 1Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.

Journal of biomedical science
|October 9, 2025
PubMed
概括

在EGFR突变非小细胞肺癌 (NSCLC) 中,编程死亡配体1 (PD-L1) 升高调节c-MET酸化. 这种PD-L1活性促进MET放大,导致对 osimertinib 治疗的抗性.

关键词:
在MET中放大放大功率.皮肤上生长因子受体氨酸激酶抑制剂.非小细胞肺癌是非小细胞肺癌.奥西默提尼布的耐药性编程死亡联手 1 编程死亡联手 1

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