与不同核酸使用模式相关的BVDV独特病毒编码区域的进化范式
Le-le An1,2, Ze-Yu Liu1, Xiao-Ting Ren1
1Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, 730030, China.
BMC veterinary research
|October 10, 2025
概括
牛病毒性腹病毒 (BVDV) 进化是由核酸使用变异形成的. 自然选择影响了子组织,特定区域显示出更强的偏差和跨基因型的保存模式.
科学领域:
- 病毒学 病毒学
- 分子进化分子进化
- 基因组学就是基因组学.
背景情况:
- 牛病毒性腹病毒 (BVDV) 呈现高突变率,导致核酸使用变异,影响其进化动态.
- 了解这些变异对于阐明BVDV的进化途径和遗传多样性至关重要.
研究的目的:
- 分析168个不同的BVDV菌株的12个编码区域的核酸使用模式.
- 确定塑造病毒编码区域的选择性因素,了解进化趋势.
- 研究突变压力和自然选择在BVDV基因组进化中的作用.
主要方法:
- 信息的分析,二核酸概率比率,相对同义的使用,有效数 (ENC) 和上下文依赖的偏差 (CDCB).
- 168个BVDV菌株的基因型分类.
- 在不同病毒区域和基因型中对核酸和子使用模式进行比较分析.
主要成果:
- 体,P7和NS4A区域显示出更强的核酸使用偏差,在基因型中保留了模式.
- 在所有地区,CpG二核酸的使用比UpA更受抑制.
- 同义代码的使用有效地显示了基因型相关的趋势和功能特定的偏好,ENC反映了突变压力和选择之间的平衡.
- CDCB分析证实了自然选择对子组织的显著影响.
结论:
- 在BVDV中,核酸和子使用模式是由突变压力和自然选择形成的.
- 特定的病毒区域 (Capsid,P7,NS4A) 呈现出不同的进化特征.
- 的使用偏差为BVDV.的进化范式和功能适应提供了洞察力.
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